In Higher Education, performance and Teaching-Learning (T-L) contexts are highly current concerns. Based on the DEDEPRO model, interdependence can be established between instructional contexts and levels of performance as they relate to the T-L process. Partitipants were 2020 pupils from two Spanish universities. Measurements of both variables were used in a quasi-experimental and correlational design. The univariate and causal analyses showed the effect of context on the T-L process and on performance; thus, the interdependent relationships between the latter and perception of the T-L process. Partial interaction effects also appeared, as well as a causal model of academic performance. Results are discussed and implications for the ECTS (European Credit Transfer System) are analyzed.