Fulminant hepatitis due to reactivation of chronic hepatitis B virus infection after allogeneic bone marrow transplantation
- 1 September 1988
- journal article
- case report
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 33 (9), 1185-1191
- https://doi.org/10.1007/bf01535798
Abstract
A case of hepatitis B reactivation following bone-marrow transplantation for leukemia in a previously healthy HBsAg carrier is reported. A number of changes in HBV serum markers were contemporary to the acute episode. All of them (increase of HBsAg concentration, conversion from anti-HBe to HBeAg, appearance of anti-HBc IgM, and of serum HBV-DNA) were suggestive of a “switching-on” of viral replication. Institution of corticosteroid treatment at the onset of the acute phase did not prevent the fatal outcome.Keywords
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