Possible role of endogenous prostaglandins in alkaline response in rat gastric mucosa damaged by hypertonic NaCl
- 1 December 1984
- journal article
- research article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 29 (12), 1142-1147
- https://doi.org/10.1007/bf01317090
Abstract
Changes in gastric potential difference (PD) and luminal pH of gastric perfusate were studied in anesthetized rats before and after application of hypertonic NaCl to the stomach for 10 min. There was a concentration-dependent reduction of PD and an increase in luminal pH after exposure to NaCl. In the stomach exposed to NaCl over 0.75 M, a significant amount of HCO3− (0.5–1.5 μmol/10min) was titrated in the lumen at pH 7.4 under cimetidine infusion (8 mg/kg/hr). After removal of hypertonic NaCl, the PD returned completely or partially to the basal values within 1 hr. Pretreatment of the rats with subcutaneously administered indomethacin (3 mg/kg) or aspirin (100 mg/kg) significantly inhibited the recovery of PD in the 1 M Nacl-treated stomach. Gastric alkaline response in the damaged mucosa was significantly attenuated in rats pretreated with indomethacin or aspirin. Intravenously administered cimetidine (8 mg/kg/hr) or subcutaneously administered 16,16-dimethyl prostaglandin E2 (3 μg/kg) abolished the inhibitory effect of indomethacin on gastric alkaline response caused by 1 M NaCl, and partially restored the PD recovery. These results indicate that endogenous prostaglandins released in the injured mucosa are probably responsible for the luminal alkalinization noted after exposure to 1 M NaCl. This process would lead to a protection against further damage and accelerate reestablishment of the mucosal integrity.Keywords
This publication has 22 references indexed in Scilit:
- Role of luminal alkalinization in repair process of ethanol-induced mucosal damage in rat stomachDigestive Diseases and Sciences, 1983
- Role of locally generated prostaglandins in adaptive gastric cytoprotectionDigestive Diseases and Sciences, 1982
- [16,16-Dimethyl prostaglandin E2, human gastric potential difference and ethanol (author's transl)].1982
- RESTITUTION OF THE SURFACE EPITHELIUM OF THE INVITRO FROG GASTRIC-MUCOSA AFTER DAMAGE WITH HYPER-OSMOLAR SODIUM-CHLORIDE - MORPHOLOGIC AND PHYSIOLOGIC CHARACTERISTICS1982
- Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosaNature, 1980
- Intravenous indomethacin and aspirin reduce basal gastric mucosal blood flow in dogsAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 1980
- Antiulcer activity of hypertonic solutions in the rat: Possible role of prostaglandinsEuropean Journal of Pharmacology, 1979
- STIMULATION OF ALKALINE SECRETION IN AMPHIBIAN-ISOLATED GASTRIC-MUCOSA BY 16,16-DIMETHYL PGE2 AND PGF2-ALPHA - PROPOSED EXPLANATION FOR SOME OF THE CYTOPROTECTIVE ACTIONS OF PROSTAGLANDINS1979
- Synthesis and metabolism of prostaglandins E2, F2α and D2 by the rat gastrointestinal tract. Stimulation by a hypertonic environment in vitroProstaglandins, 1978
- Stimulation of prostaglandin output from rat stomach by hypertonic solutionsEuropean Journal of Pharmacology, 1977