MDM2–HDAC1-mediated deacetylation of p53 is required for its degradation
Top Cited Papers
- 15 November 2002
- journal article
- Published by Springer Nature in The EMBO Journal
- Vol. 21 (22), 6236-6245
- https://doi.org/10.1093/emboj/cdf616
Abstract
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.Keywords
This publication has 33 references indexed in Scilit:
- Post‐translational modifications and activation of p53 by genotoxic stressesEuropean Journal of Biochemistry, 2001
- Control of p53 ubiquitination and nuclear export by MDM2 and ARF.2001
- p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2The EMBO Journal, 2001
- Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and UbiquitinationMolecular and Cellular Biology, 2000
- Deacetylation of p53 modulates its effect on cell growth and apoptosisNature, 2000
- MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteinsProceedings of the National Academy of Sciences, 2000
- Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated DegradationMolecular and Cellular Biology, 2000
- An intact HDM2 RING-finger domain is required for nuclear exclusion of p53Nature Cell Biology, 2000
- The MDM2 RING-finger domain is required to promote p53 nuclear exportNature Cell Biology, 2000
- Stress Signals Utilize Multiple Pathways To Stabilize p53Molecular and Cellular Biology, 2000