Endogenous activation of glycine and NMDA receptors in lamprey spinal cord during fictive locomotion
Open Access
- 1 August 1989
- journal article
- research article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 9 (8), 2792-2800
- https://doi.org/10.1523/jneurosci.09-08-02792.1989
Abstract
Strychnine is shown to abolish left-right alternation in fictive locomotion induced by sensory stimulation. Robust rhythmic activity, characterized by left-right coactivation at each segmental level, is seen in the presence of strychnine at all doses used (0.5–20 microM). The proportion of the cycle occupied by the ventral root bursts and the rostral-caudal coordination is similar to that seen in the absence of strychnine. Furthermore, the rhythm is abolished by cis-2,3-piperidine dicarboxylic acid (PDA), 2-amino-5-phosphonovalerate (APV), or the removal of Mg2+ from the perfusate, as in the absence of strychnine. Voltage clamp was applied to ventral horn neurons during stimulation in the presence of strychnine, with holding potentials negative to the plateau potential associated with a ventral root burst but positive to the potential in the interburst. Inward current was seen during the ventral root burst, but no outward current was seen at burst termination or during the interburst. The results indicate that in fictive locomotion induced by endogenous release of NMDA receptor agonists, left-right alternation is dependent on glycinergic transmission. Furthermore, evidence is provided that in the absence of glycinergic transmission, burst termination may depend on NMDA receptor- linked voltage-sensitive processes.This publication has 18 references indexed in Scilit:
- The ionic mechanisms underlying N-methyl-d-aspartate receptor-induced, tetrodotoxin-resistant membrane potential oscillations in lamprey neurons active during locomotionNeuroscience Letters, 1985
- Reciprocal inhibitory interneurones in the Xenopus embryo spinal cord.The Journal of Physiology, 1985
- Descending control and sensory gating of ‘fictive’ swimming and turning responses elicited in an in vitro preparation of the lamprey brainstem/spinal cordBrain Research, 1984
- Fictive locomotion in the lamprey spinal cord in vitro compared with swimming in the intact and spinal animal.The Journal of Physiology, 1984
- Initiation and sensory gating of ‘fictive’ swimming and withdrawal responses in an in vitro preparation of the lamprey spinal cordBrain Research, 1983
- On the control of myotomal motoneurones during “fictive swimming” in the lamprey spinal cord in vitroActa Physiologica Scandinavica, 1983
- Identification of interneurons with contralateral, caudal axons in the lamprey spinal cord: synaptic interactions and morphologyJournal of Neurophysiology, 1982
- Activities of identified interneurons, motoneurons, and muscle fibers during fictive swimming in the lamprey and effects of reticulospinal and dorsal cell stimulationJournal of Neurophysiology, 1982
- Patterns of synaptic inhibition in motoneurons and interneurons during fictive swimming in the lamprey, as revealed by Cl? injectionsJournal of Comparative Physiology A, 1982
- The neuronal correlate of locomotion in fishExperimental Brain Research, 1980