Severe transient hyperinsulinaemic hypoglycaemia: two neonates without predisposing factors and a review of the literature
- 1 January 2004
- journal article
- case report
- Published by Springer Nature in European Journal of Pediatrics
- Vol. 163 (1), 38-41
- https://doi.org/10.1007/s00431-003-1328-2
Abstract
We report on transient hyperinsulinism (HI), presenting as severe congenital HI, in two neonates born without intrauterine growth restriction, maternal diabetes, perinatal asphyxia or Rhesus/platelet isoimmunisation. The neonates developed early ( Conclusion:transient hyperinsulinism can occur in newborns delivered uneventfully without significant perinatal complications. The unusual sensitivity to medical treatment in these cases of neonatal-onset hyperinsulinaemic hypoglycaemia underscores the importance of careful medical management of severe congenital hyperinsulinism. Careful consideration of the indication and if necessary, timing and extent of pancreatectomy is required, while maintaining euglycaemia to protect the developing brain.Keywords
This publication has 26 references indexed in Scilit:
- Long-term follow-up of 114 patients with congenital hyperinsulinismActa Endocrinologica, 2003
- Ten years' experience of persistent hyperinsulinaemic hypoglycaemia of infancyJournal of Paediatrics and Child Health, 2001
- Persistent hyperinsulinaemic hypoglycaemia of infancy: a heterogeneous syndrome unrelated to nesidioblastosisArchives of Disease in Childhood: Fetal & Neonatal, 2000
- Clinical Features of 52 Neonates with HyperinsulinismNew England Journal of Medicine, 1999
- Hyperinsulinisme transitoire avec hypoglycémie par asphyxie néonataleArchives de Pédiatrie, 1999
- Hyperinsulinism and Hyperammonemia in Infants with Regulatory Mutations of the Glutamate Dehydrogenase GeneNew England Journal of Medicine, 1998
- Association of Isoimmune Thrombocytopenia and Neonatal Hyperinsulinism/HypoglycemiaAmerican Journal of Perinatology, 1994
- Hyperinsulinaemic hypoglycaemia in small for dates babies.Archives of Disease in Childhood, 1990
- HYPERINSULINISM IN ASPHYXIATED AND SMALL-FOR-DATES INFANTS WITH HYPOGLYCAEMIAThe Lancet, 1984
- Human Fetal Insulin Response to Sustained Maternal HyperglycemiaNew England Journal of Medicine, 1970