Fidaxomicin versus Vancomycin forClostridium difficileInfection
Top Cited Papers
- 3 February 2011
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 364 (5), 422-431
- https://doi.org/10.1056/nejmoa0910812
Abstract
Clostridium difficile infection is a serious diarrheal illness associated with substantial morbidity and mortality. Patients generally have a response to oral vancomycin or metronidazole; however, the rate of recurrence is high. This phase 3 clinical trial compared the efficacy and safety of fidaxomicin with those of vancomycin in treating C. difficile infection.This publication has 36 references indexed in Scilit:
- OPT-80 Eliminates Clostridium difficile and Is Sparing of Bacteroides Species during Treatment of C. difficile InfectionAntimicrobial Agents and Chemotherapy, 2009
- Clinical Outcomes, Safety, and Pharmacokinetics of OPT-80 in a Phase 2 Trial with Patients with Clostridium difficile InfectionAntimicrobial Agents and Chemotherapy, 2009
- In Vitro Activity of OPT-80 Tested against Clinical Isolates of Toxin-Producing Clostridium difficileAntimicrobial Agents and Chemotherapy, 2008
- Both Oral Metronidazole and Oral Vancomycin Promote Persistent Overgrowth of Vancomycin-Resistant Enterococci during Treatment of Clostridium difficile -Associated DiseaseAntimicrobial Agents and Chemotherapy, 2008
- Safety, Tolerance, and Pharmacokinetic Studies of OPT-80 in Healthy Volunteers following Single and Multiple Oral DosesAntimicrobial Agents and Chemotherapy, 2008
- Clinical Severity of Clostridium difficile PCR Ribotype 027: A Case-Case StudyPLOS ONE, 2008
- Comparison of Seven Techniques for Typing International Epidemic Strains of Clostridium difficile : Restriction Endonuclease Analysis, Pulsed-Field Gel Electrophoresis, PCR-Ribotyping, Multilocus Sequence Typing, Multilocus Variable-Number Tandem-Repeat Analysis, Amplified Fragment Length Polymorphism, and Surface Layer Protein A Gene Sequence TypingJournal of Clinical Microbiology, 2008
- Increase inClostridium difficile–related Mortality Rates, United States, 1999–2004Emerging Infectious Diseases, 2007
- In Vitro Activities of 15 Antimicrobial Agents against 110 Toxigenic Clostridium difficile Clinical Isolates Collected from 1983 to 2004Antimicrobial Agents and Chemotherapy, 2007
- Molecular Analysis of Clostridium difficile PCR Ribotype 027 Isolates from Eastern and Western CanadaJournal of Clinical Microbiology, 2006