Effect of Cortisol on Gastric Ulcers of the Shay Rat

Abstract

Summary 1) Cortisol (COL) given at the daily dose of 10 mg inhibited to a large extent the development of rumenal ulcers in pylorus ligated rats. It also reduced markedly the incidence of gastric perforation. It is suggested that this protection is due to the antiphlogistic property of COL by which this hormone counteracts the initial inflammatory reaction in the rumen wall brought about normally by concentrated gastric juice. 2) At the same time, COL promoted formation of ulcers in the corpus of the stomach, whether or not the pylorus was ligated.