Chemotherapy of Neoplastic Disease

Abstract

From the large array of substances under laboratory and clinical study, several have been established as useful in the management of patients with inoperable neoplastic disease. These agents are discussed in the order of their value to the clinician, as judged by their unique therapeutic activity and their general clinical effectiveness. Estrogens Estrogens are useful in the treatment of carcinoma of the prostate and, to a considerably lesser extent, in carcinoma of the breast. With the fundamental work of Huggins²¹⁴ in establishing the role of the steroid hormones in prostatic physiology, the therapeutic value of castration and estrogen therapy in . . .