The Role of Tocopherol in Oxygen-Induced Retinopathy: Kitten Model
- 1 June 1977
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 59 (6), 998-1005
- https://doi.org/10.1542/peds.59.6.998
Abstract
The effect of tocopherol (vitalnin E) on oxygen-induced retinopathy was studied in 75 kittens following the development of a 12-point scoring system to quantitate the degree of retinopathy seen at three weeks. The tocopherol was found to be beneficial when given daily from the day of birth (P < .0001) with oxygen exposures of two to three days (79% F1O2) beginning on day 3. Caution is urged in applying these data to humans because (1) hepatosplenomegaly was noted in the treated animals, and (2) the kitten model of oxygen-induced retinopathy is not entirely satisfactory,Keywords
This publication has 1 reference indexed in Scilit:
- Retrolental Fibroplasia in Premature Infants*American Journal of Ophthalmology, 1949