Hyperplastic and Early Neoplastic Lesions of the Liver in Buffalo Strain Rats of Various Ages Given Subcutaneous Carbon Tetrachloride2

Abstract

Inbred Buffalo male and female rats, 4, 12, 24, and 52 weeks old, were given subcutaneous injections of carbon tetrachloride. Preneoplastic and early neoplastic lesions of the parenchymal cells developed in the liver. The 24- and 52-week-old animals of both sexes had more hyperplastic nodules as well as an occasional small hepatocellular carcinoma. The number of hyperplastic lesions per liver and size of lesions were larger in females than in males. In contrast, the fluorenylamines have been more effective in the males. Four-day-old animals given carbon tetrachloride died with hepatic and renal necrosis.