Specificity of IgG subclass antibodies in different clinical manifestations of leprosy
Open Access
- 1 May 1992
- journal article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 88 (2), 253-257
- https://doi.org/10.1111/j.1365-2249.1992.tb03069.x
Abstract
We analysed specific IgG subclasses levels to Mycobacterium leprae sonicate extract (MSE), lipoarabinomannan B (LAM) and phenolic glycolipid I (PGL-I) in the sera of leprosy patients with different clinical manifestations. IgG2 was found to be the predominant antibody to MSE regardless of clinical manifestations, and IgG 1 response was mostly seen in lepromatous patients. IgG3 reacted only rarely but IgG4 reacted relatively more in certain clinical groups such as borderline lepromatous and lepromatous with erythema nodosum leprosum (ENL) reaction. Most of the IgG subclass responses to MSE could be accounted for reactivity with LAM, suggesting that LAM is the major immunogen involved in the pathogenesis of leprosy. In contrast to LAM. PGL-I antigen showed considerably lower reactivities for IgG subclasses. An association between IgG subclass responses and clinical manifestations of leprosy was also seen. Whereas borderline lepromatous patients were found to have significantly higher levels of IgG2 and lgG4 to MSE, lepromatous patients had elevated levels of IgG I and lower levels of IgG2. An interesting observation, however, was the significantly higher levels of IgG2 to LAM in the pure neuritic leprosy patients.Keywords
This publication has 28 references indexed in Scilit:
- A clinical, immunological, and histological study of neuritic leprosy patients.1991
- Selective IgG subclass deficiency: quantification and clinical relevanceClinical and Experimental Immunology, 1990
- Early antibody responses in human schistosomiasisClinical and Experimental Immunology, 1990
- LeprosyClinical Microbiology Reviews, 1988
- Leprosy and the Leprosy Bacillus: Recent Developments in Characterization of Antigens and Immunology of the DiseaseAnnual Review of Microbiology, 1987
- IgM and IgG Antibodies to Phenolic Glycolipid I from Mycobacterium leprae in Leprosy: Insight into Patient Monitoring, Erythema Nodosum Leprosum, and Bacillary PersistenceJournal of Investigative Dermatology, 1986
- Immunological Unresponsiveness in LeprosyImmunological Reviews, 1984
- Immunological assessment of sera of leprosy patients.1979
- Serum Immunoglobulins in Leprosy Patients with Different Spectra of Clinical ManifestationsExperimental Biology and Medicine, 1972
- Classification of leprosy according to immunity. A five-group system.1966