STUDIES ON THE ACTION OF DIURETICS I. THE EFFECT OF EUPHYLLIN AND SALYRGAN UPON GLOMERULAR FILTRATION AND TUBULAR REABSORPTION 1

Abstract

Rehberg''s creatinine method for measuring glomerular filtration and tubular reabsorption was used to investigate the diuretic action of euphyllin, salyrgan and intraven. normal saline sol. in the dog. During euphyllin diuresis the calculated amount of glomerular filtration was consistently increased, while tubular reabsorption showed no constant change. Salyrgan diuresis was characterized by a considerable decrease in the percentage of fluid reab-sorbed in the tubules. The amount of filtration was seldom increased significantly. The intravenous injection of normal saline sol. characteristically increased the rate of glomerular filtration. When saline was injected continuously at a rate of 10 cc. per min. there was in addition considerable decrease in reabsorption.