Every patient on ergot therapy for headaches should be carefully watched for toxic manifestations, and the pulses of the hands and feet should be periodically checked. At the first indication of toxicity, the administration of the drug should be stopped, and measures to produce vasodilatation should be initiated. Vasodilating drugs may be tried. If the spasm is severe and the circulation of the limb critical, sympathetic blocks and, if this is not sufficient, sympathectomy with periarterial stripping should be performed. In the case here presented a 42-year-old woman had severe arteriospasm following the use of ergotamine tartrate suppositories for constant headaches of long standing. The patient completely recovered after bilateral sympathectomy, periarterial stripping, the administration of vasodilator drugs, and withdrawal of the ergot alkaloid.