Differential effects of amphetamine on food and water intake in rats with lateral hypothalamic lesions.

Abstract

Amphetamine sulphate produced significantly greater depression of food intake in normal rats than in rats with lateral hypothalamic lesions, suggesting that amphetamine reduces food intake by inhibiting the lateral hypothalamus. The 2 groups did not differ significantly with respect to the action of amphetamine on water intake (suggesting different central sites of action of this drug for food and water intake) or with respect to water intake following injections of chlorpromazine HC1 or neostigmine methylsufate.