Lipoid Substance in the Cells of Proximal Convoluted Tubules of the Kidneys of Young Rats on a Choline-deficient Diet

Abstract

In a series of Sudan IV-stained frozen sections from kidneys of young choline-deficient rats, fatty droplets were consistently observed in the cells of the proximal convoluted tubules. The animals were killed at daily intervals after being placed on the choline-deficient diet. The fatty changes were usually visible by the 3d day, reaching a maximum on the 6th or 7th day, when congestion, hemorrhage, and cortical necrosis were demonstrable. This fat may be important in the production of other lesions of the "hemorrhagic" kidney.