Primary structures of human protein kinase C βI and βII differ only in their C‐terminal sequences
- 19 October 1987
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 223 (1), 138-142
- https://doi.org/10.1016/0014-5793(87)80524-0
Abstract
Two types of cDNA clones encoding human protein kinase C (PKC) were isolated from a spleen cDNA library using rabbit protein kinase C βI/βII cDNA as a hybridization probe. Nucleotide sequence analyses of these cDNA inserts revealed complete primary structures of two distinct types of human protein kinase C βI and βII which differ only in their C‐terminal 50 or 52 amino acid residues. It was concluded that there exist four distinct types of PKC, PKC α, βI, βII and γ, in human as well as rabbit, and that the corresponding sequences are strictly conserved among mammalian species.Keywords
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