Two types of complementary DNAs of rat brain protein kinase C
Open Access
- 6 October 1986
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 206 (2), 347-352
- https://doi.org/10.1016/0014-5793(86)81010-9
Abstract
Two types of complementary DNA clones for rat brain protein kinase C were isolated. These clones encode 671 and 673 amino acid sequences, which differ from each other only in the carboxyl‐terminal regions of approx. 50 amino acid residues. This difference seems to result from alternative splicing. Elucidation of the sequences of these cDNA clones as well as some peptides from the purified rat brain enzyme suggests the existence of an additional species of protein kinase C in this tissue. It is attractive to imagine that the heterogeneity of protein kinase C may reflect diverse pathways of signal transduction into the cell.Keywords
This publication has 20 references indexed in Scilit:
- Cloning of rat brain protein kinase C complementary DNAFEBS Letters, 1986
- Studies and Perspectives of Protein Kinase CScience, 1986
- Rapid purification of protein kinase C by high performance liquid chromatographyBiochemical and Biophysical Research Communications, 1986
- Alternative 5′ exons in c-abl mRNACell, 1986
- Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicingNature, 1984
- cGMP-dependent protein kinase, a chimeric protein homologous with two separate protein familiesBiochemistry, 1984
- Initiation of translation at internal AUG codons in mammalian cellsNature, 1984
- TECHNOLOGICAL EXAMINATION OF LOW‐FIRED TERRACOTTA STATUES FROM AYIA IRINI, KEAArchaeometry, 1982
- Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide productsNature, 1982
- The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genesCell, 1981