Synthesis and antiinflammatory activity of metabolites of piroxicam

Abstract

Four possible pyridine monohydroxylated metabolites of the antiinflammatory agent piroxicam were synthesized for comparison with a natural pyridine-hydroxylated metabolite of this compound. Another metabolite of piroxicam, derived from dehydration of the parent drug, was made and characterized. The antiinflammatory activity of these compounds and 4 other known metabolites of piroxicam was measured in the carrageenan-induced rat paw edema model and all were less active than piroxicam itself.