Guanidination of a peptide side chain amino group on a solid support*
- 1 May 1991
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 37 (5), 425-429
- https://doi.org/10.1111/j.1399-3011.1991.tb00757.x
Abstract
A novel guanidination method of converting a peptide side chain amino group to a guanidino group on a solid support is described. Four guanidinating reagents were evaluated using a model tetrapeptide attached to a polystyrene resin. Experimental data indicate that the two nitroguanidinating reagents, but not the two tosylguanidinating reagents, can be used effectively in solid phase peptide synthesis.Keywords
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