Resistance to Interferon of a Human Adenocarcinoma Cell Line, HEC-1, and its Sensitivity to Natural Killer Cell Action
Open Access
- 1 January 1981
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 52 (1), 177-181
- https://doi.org/10.1099/0022-1317-52-1-177
Abstract
A human endometrial cancer cell line, HEC-1, was resistant to the antiviral and anticellular action of interferon. HEC-1 cells were susceptible to the cytotoxicity of natural killer (NK) cells and interferon enhanced such NK activity. When HEC-1 cells were treated with interferon, sensitivity of HEC cells to the cytotoxicity of NK cells was not suppressed.This publication has 15 references indexed in Scilit:
- Interferon-induced enzymatic activities and their role in the antiviral stateCell, 1979
- Comparison of the Suppression of Cell and Virus Growth in Transformed Human Cells by Leukocyte and Fibroblast InterferonJournal of General Virology, 1979
- Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.Proceedings of the National Academy of Sciences, 1978
- Antitumor effects of interferonBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1978
- Interferon and spontaneous cytotoxicity in man. I. Enhancement of the spontaneous cytotoxicity of peripheral lymphocytes by human leukocyte interferonInternational Journal of Cancer, 1978
- Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis.The Journal of Experimental Medicine, 1978
- SIMILARITIES AMONG FACTORS THAT RENDER MACROPHAGES TUMORICIDAL IN LYMPHOKINE AND INTERFERON PREPARATIONS1978
- Presence of human chromosome 21 alone is sufficient for hybrid cell sensitivity to human interferonJournal of Virology, 1978
- On the varied biologic effects of interferonCellular Immunology, 1977
- Effects of Interferon on Cell and Virus Growth in Transformed Human Cell LinesJournal of General Virology, 1976