Postexposure HIV Prophylaxis Regimen
Open Access
- 1 January 2005
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 40 (1), 205-206
- https://doi.org/10.1086/426692
Abstract
SIR—Bassett et al. [1] provide an evidence-based decision model to guide the choice of the optimal postexposure prophylaxis (PEP) regimen for occupational exposure to human immunodeficiency virus (HIV). In their mathematical approach, the authors essentially balance the toxicity of 2-drug versus 3-drug regimens (i.e., a regimen that combines 2 nucleoside reverse-transcriptase inhibitors [NRTIs], with or without a protease inhibitor [PI]) and the prevalence of antiretroviral resistance, and they conclude that, under many conditions, the benefit of completing a full course of a 2-drug regimen exceeds the benefit of adding a third antiretroviral.Keywords
This publication has 3 references indexed in Scilit:
- Two Drugs or Three? Balancing Efficacy, Toxicity, and Resistance in Postexposure Prophylaxis for Occupational Exposure to HIVClinical Infectious Diseases, 2004
- Antiretroviral Drug Resistance in Human Immunodeficiency Virus–Infected Source Patients for Occupational Exposures to Healthcare WorkersInfection Control & Hospital Epidemiology, 2003
- Post-exposure prophylaxis for HIV infectionThe Lancet, 2000