Postexposure HIV Prophylaxis Regimen

Abstract
SIR—Bassett et al. [1] provide an evidence-based decision model to guide the choice of the optimal postexposure prophylaxis (PEP) regimen for occupational exposure to human immunodeficiency virus (HIV). In their mathematical approach, the authors essentially balance the toxicity of 2-drug versus 3-drug regimens (i.e., a regimen that combines 2 nucleoside reverse-transcriptase inhibitors [NRTIs], with or without a protease inhibitor [PI]) and the prevalence of antiretroviral resistance, and they conclude that, under many conditions, the benefit of completing a full course of a 2-drug regimen exceeds the benefit of adding a third antiretroviral.