Serum PAPP‐A and free β‐hCG are first‐trimester screening markers for down syndrome
- 1 November 1994
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 14 (11), 1043-1047
- https://doi.org/10.1002/pd.1970141106
Abstract
Serum measurements of pregnancy-associated plasma protein A (PAPP-A) and the free β-human chorionic gonadotrophin (hCG) subunit were made in 13 women with Down syndrome (DS) pregnancies and six other women with fetal aneuploidy ascertained at chorionic villus sampling (CVS), as well as 89 women with contemporaneous normal control pregnancies. Median serum PAPP-A measurements (0·31 MOM, 95 per cent confidence interval (CI) 0·22–0·65 vs. normal 1·06, 95 per cent CI 0·89–1·20) were lower and free β-hCG subunit measurements (1·13 MOM, 95 per cent CI 0·93–2·63 vs. normal 0·91, 95 per cent CI 0·79–1·03) were higher at statistically significant levels. Receiver operator characteristic (ROC) curves showed that the highest sensitivity for detection, 71·2 per cent (95 per cent CI 54·7–87·6 per cent), was for depressed PAPP-A levels; the combination of low serum PAPP-A levels, maternal age, and elevated free β-hCG levels yielded a detection rate of 78·9 per cent (95 per cent CI 64·9–92·8 per cent) of the affected pregnancies at 8–12 weeks' gestation.Keywords
This publication has 11 references indexed in Scilit:
- Serum PAPP‐A measurements in first‐trimester screening for Down syndromePrenatal Diagnosis, 1993
- Serum PAPP‐A levels are depressed in women with fetal Down syndrome in early pregnancyPrenatal Diagnosis, 1993
- Low maternal serum levels of pregnancy associated plasma protein A (PAPP‐A) in the first trimester in association with abnormal fetal karyotypeBJOG: An International Journal of Obstetrics and Gynaecology, 1993
- First trimester concentrations of pregnancy associated plasma protein A and placental protein 14 in Down's syndrome.BMJ, 1992
- Free β-hCG as first-trimester marker for fetal trisomyThe Lancet, 1992
- Ultrasound and Biochemical Assessment of First Trimester PregnancyPublished by Springer Nature ,1991
- Estimating a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum alpha‐fetoprotein levelBJOG: An International Journal of Obstetrics and Gynaecology, 1987
- Radioimmunoassay for pregnancy-associated plasma protein A.Clinical Chemistry, 1982
- Outliers in clinical chemistry quality-control schemes.Clinical Chemistry, 1979