Natriuresis in Conscious Dogs during Arginine Vasopressin Infusion and after Oxytocin Injection.

Abstract

When arginine vasopressin is infused i. v. into hydrated, conscious dogs, at a rate of 1 mU/kgm x hour, it causes an initial natriuresis that rapidly subsides. Antidiuresis persists for the duration of the infusion. Oxytocin, in doses of 7 mU/kg, produces natriuresis only if administered to dogs with low urine flow rates produced by withholding water or by infusing vasopressin. Antidiuresis appears to be a prerequisite for the natriuretic response to oxytocin.