A CONTIGUOUS, 3-MB PHYSICAL MAP OF XQ28 EXTENDING FROM THE COLOR-BLINDNESS LOCUS TO DXS15
- 1 December 1989
- journal article
- research article
- Vol. 45 (6), 873-882
Abstract
Using pulsed-field gel electrophoresis (PFGE), we have generated a 3-megabase (Mb) physical map of Xq28, a region of the human genome known to contain many disease loci. We have determined the location of the genes for protan/deutan colorblindness (R/GCP), factor VIII (F8), glucose-6-phosphate dehydrogenase (G6PD), and a series of RFLPs and have derived the following order for this region: R/GCP-GdX-G6PD-F8-DXS115-DXS33-DXS134-DXS15. Using newly isolated probes, we have also established the direction of transcription of F8 within the map and have localized CpG islands flanking this gene.This publication has 27 references indexed in Scilit:
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