Effect of hypnotic and anxiolytic agents on regional concentration of acetylcholine in rat brain
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 301 (3), 157-161
- https://doi.org/10.1007/bf00507031
Abstract
Pentobarbital (30 and 60 mg/kg) and chloral hydrate (300 and 600 mg/kg) administered in anesthetic/hypnotic doses produced significant increases in acetylcholine concentration in the cerebral cortex, striatum, hippocampus and brainstem. Hypnotic/anxiolytic agents like diazepam, flurazepam (100 mg/kg each) and triazolam (30 mg/kg) significantly increased the acetylcholine concentration only in the cerebral cortex and striatum. Alprazolam and ketazolam had no significant effect on regional distribution of acetylcholine in the brain. The results have been discussed with respect to the role of central cholinergic system in anesthetic and hypnotic actions of these drugs.This publication has 22 references indexed in Scilit:
- EARLY CHANGES IN ACETYLCHOLINE POOLS IN THE HIPPOCAMPUS OF THE RAT BRAIN AFTER SEPTAL LESIONSJournal of Neurochemistry, 1975
- Action 0f hemicholinium-3 on cholinergic nerve terminals after alteration of neuronal impulse flowNeuropharmacology, 1974
- Determination of Drug-Induced Changes in Sleep Quality Based on Digital Computer “Sleep Prints”Pharmacopsychiatry, 1974
- Choline and acetylcholine: Regional distribution and effect of degeneration of cholinergic nerve terminals in the rat hippocampusNeuropharmacology, 1973
- Cholinergic neurons: effect of acute septal lesion on acetylcholine and choline content of rat hippocampusBrain Research, 1973
- Acetylcholine Release within the Cat Striatum during the Sleep–Wakefulness CycleNature, 1973
- Effect of l-DOPA on brain acetylcholine and choline in ratsNeuropharmacology, 1973
- Digital Computer Analyzed Awake and Sleep EEG (Sleep Prints) in Predicting the Effects of a Triazolobenzodiazepine (U-31, 889)Pharmacopsychiatry, 1972
- Effect of central stimulants and depressants on mouse brain acetylcholine and choline levelsEuropean Journal of Pharmacology, 1972
- REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐IJournal of Neurochemistry, 1966