Ocular Pigmentation, Extrapyramidal Symptoms and Phenothiazine Dosage

Abstract

Oculo-cutaneous pigmentation has often been reported (Brit med. J., 1967) in patients receiving heavy doses of phenothiazines. This paper sets out to investigate, (a) the incidence of ocular pigmentation in such patients; (b) whether the measures suggested by Valentine and Jardine (1966) for minimizing this complication are effective; (c) the relationship of ocular pigmentation to extrapyramidal symptoms (and hence whether the pigmentation can be regarded as a sign of brain damage).