STUDIES ON CHEMOTHERAPY OF VACCINIA VIRUS
- 1 February 1951
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 61 (2), 127-134
- https://doi.org/10.1128/jb.61.2.127-134.1951
Abstract
A test for antivaccinia virus agents is descr., using chick embryos. With virus concns. of approx. 20 to 3500 LD50, the reciprocal survival time has a constant variance and is linearly related to the logarithm of the virus concn. Accordingly, a 6-point assay form of test was used and the activity of antiviral agents denoted by the logarithm of the factor by which they reduce the effective virus concn. The results of a series of tests of an active compound, p-aminobenzaldehyde-3-thiosemicarbazone, are given. Analysis of variance confirms the assumptions of the tests and supplementary expts. confirm the numerical value for the activity.Keywords
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