Plasma levels of d-amphetamine in hyperactive children
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 62 (2), 133-140
- https://doi.org/10.1007/bf00427126
Abstract
Amphetamine has been clearly documented to be an efficacious treatment for hyperactive children. The pharmacokinetics of amphetamine have been studied in adults, but not in children. Sixteen male children who scored >2 SD from norms on Factors I and IV of Conners's Teacher Rating Scale and who were not excluded for reasons to do with medical or psychiatric conditions, intelligence, or age, had a plasma d-amphetamine apparent elimination half-life of 6.8±0.5 h. Peak plasma level occurred between 3 and 4 h (62.7±3.8 and 65.9±3.6 ng/ml, respectively). Six of these children had a repeat study and there were no significant differences within subject in apparent elimination half-lives and attained peak blood levels. The variation in plasma levels was greater during absorption than during elimination. Both behavioral and motor activity resonses as analyzed by differences between amphetamine and placebo days (by paired t-tests) indicate significant responses between hours 1–4; however, these responses do not correlate with plasma amphetamine levels; they occur during the absorption phase. The decreased response to later similar plasma levels of d-amphetamine may be related to depletion of catecholamine stores, to replacement by a ‘false neurotransmitter’ metabolite of amphetamine, or to alteration in receptor sensitivity.Keywords
This publication has 77 references indexed in Scilit:
- CSF monoamine metabolites in children with minimal brain dysfunction: Evidence for alteration of brain dopamineThe Journal of Pediatrics, 1977
- Postoperative Ileus in the RatAnnals of Surgery, 1973
- Amphetamines: New radioimmunoassayFEBS Letters, 1973
- Postoperative gastric ileusDigestive Diseases and Sciences, 1973
- Predicting Amphetamine Response in Hyperkinetic Children by Electronic PupillographyPharmacopsychiatry, 1973
- Serotonin concentrations in whole blood of hyperactive childrenThe Journal of Pediatrics, 1971
- Symptom Patterns in Hyperkinetic, Neurotic, and Normal ChildrenChild Development, 1970
- PLATELET-SEROTONIN LEVEL IN CHILDREN WITH " MINIMAL BRAIN DYSFUNCTION "The Lancet, 1969
- Amphetamine Blood and Urine Levels in ManJournal of Pharmaceutical Sciences, 1969
- Hyperkinetic behavior syndrome in childrenThe Journal of Pediatrics, 1957