Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
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Open Access
- 17 February 2010
- journal article
- review article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 86 (2), 236-242
- https://doi.org/10.1093/cvr/cvq045
Abstract
The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and the mobilization and homing of bone marrow-derived angiogenic cells. This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models.Keywords
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