Influence of aortic coarctation on myocardial glucose-6-phosphate dehydrogenase

Abstract

Alterations in the activity of myocardial glucose-6-phosphate dehydrogenase were studied in rats with experimentally produced cardiac hypertrophy. Six days after aortic coarctation, enzyme activity was increased to more than 200% of the control values when expressed either per gram wet weight or per organ. Administration of cycloheximide resulted in a significant inhibition of the increase in cardiac glucose-6-phosphate dehydrogenase noted after constriction. It is conceivable that the augmentation in the activity of this enzyme may be related to the increases in RNA and protein synthesis observed during development of cardiac hypertrophy.