Analysis of in vitro activities and modes of action of synthetic antimicrobial peptides derived from an α-helical ‘sequence template’
Open Access
- 3 January 2008
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 61 (2), 341-352
- https://doi.org/10.1093/jac/dkm479
Abstract
Objectives Cationic antimicrobial peptides (AMPs) are indispensable components of innate immune systems and promising candidates for novel anti-infective strategies. We rationally designed a series of peptides based on a template derived from known α-helical AMPs, which were then analysed regarding efficacy against clinical isolates and antibiotic mechanisms.Keywords
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