Influence of 9-Alpha Fluorohydrocortisone on Contractility and Na Content of Isolated Cat Papillary Muscle.

Abstract

-A new method is described for making permanent and simultaneous recordings of the contractions of paired papillary heart muscle preparations. Utilizing this method it was observed that the addition of 9-alpha fluorohydrocortisone in a concentration between 0.5 to 1.0 [mu]g/ml of perfusate, was followed by a marked increase in the force of contractions. In addition, there was an average 2-fold increase in the uptake of Na22 by the treated muscle, as opposed to the control.