Studies on sulphatases. 17. The action of surface-active agents on the arylsulphatase C of rat liver
- 1 June 1957
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 66 (2), 363-368
- https://doi.org/10.1042/bj0660363
Abstract
The arylsulfatase C of rat-liver microsomes was solubilized by cationic and non-ionic surface-active agents, solubilization being accompanied by activation of the enzyme. Both the solubilizing and activating effects were associated with micelle formation by the detergents. Anionic surface-active agents in the ionic form acted as strong competitive inhibitors of the enzyme but solubilization of the remaining activity was achieved and was associated with micelle formation by the detergent. In all cases the solubilized arylsulfatase C became insoluble on removal of the detergent.Keywords
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