Anaphylactic Reaction of Denervated Skeletal Muscle in the Guinea Pig

Abstract

Muscle strips taken from chronically denervated hemidiaphragms of guinea pigs immunized to ovalbumin react in vitro to the administration of small amounts of this protein with a contraction similar to that of visceral muscle in the Schultz-Dale reaction. A sustained shortening is produced by histamine on denervated diaphragmatic muscle from both sensitized and nonsensitized guinea pigs.