In the last ten years, European Commission has deeply investigated the concern of Powered Two Wheelers (PTW) accidents in the European roads, trying to focus on the improvement of road safety through the introduction of Intelligence Transportation Systems. Several new European research projects involving PTWs have been promoted by EC to resolve this gap: SAFERIDER aiming to enhance rider safety, comfort and, hopefully, reduce fatalities. Four Advanced Riding Assistance Systems (ARAS, or so called in literature ADAS, with Driver instead of Rider) and four In-Vehicle Information Systems (IVIS) will be designed, studied and validated to create a new vehicle concept , with high technical and innovation values. To reach this goal, a priori in-depth accident analyses are performed to discover causes and most common scenarios leading to accidents. Following this, the development of a common architecture able to host ARAS and IVIS is on progress and will be finalized in the next months. To close the loop between vehicle and rider, Human Machine Interface (HMI) concepts are designed and implemented in different ways [1]. A major innovation and breakthrough of the SAFERIDER project, lies with the fact being the first project that considers the integration of several sub-systems on PTWs.