Immunohistopathologic study on carcinoembryonic antigen (CEA)-like material and immunoglobulin a in gastric malignancies
- 1 November 1979
- Vol. 44 (5), 1606-1614
- https://doi.org/10.1002/1097-0142(197911)44:5<1606::aid-cncr2820440511>3.0.co;2-r
Abstract
Immunofluorescent staining for carcinoembryonic antigen (CEA)-like material and immunoglobulin A (IgA) was performed on 54 gastric specimens showing normal mucosa and various lesions including malignancy. Both CEA-like material and IgA were demonstrated in normal mucosa and benign and malignant epithelial lesions. Abnormal findings in respect of CEA-like material included staining of cell membranes with disordered pattern and increased cytoplasmic staining. Several staining characteristics for CEA-like material were shown by various types of malignant epithelial tumors. This staining provides a means of distinguishing anaplastic carcinoma from histiocytic lymphoma, as the latter does not demonstrate CEA-like material. IgA was consistently absent in anaplastic carcinomas, but was noted on the inner surface of tubular components in the differentiated adenocarcinomas, indicating functional preservation in the differentiated tumors. Immunohistochemical staining for CEA-like material and IgA is considered to be useful in the structural and functional study of gastric malignancies.This publication has 25 references indexed in Scilit:
- A shorter immunoperoxidase technique for the demonstration of carcinoembryonic antigen and other cell products.Journal of Clinical Pathology, 1977
- Oncofetal and Other Tumor-Associated Antigens of the Human Digestive SystemPublished by Springer Nature ,1976
- Carcinoembryonic antigen (CEA) assayA laboratory adjunct in the diagnosis and management of cancerHuman Pathology, 1974
- Carcinoembryonic antigen (CEA) in gastrointestinal and extragastrointestinal tumors and its relationship to tumor‐cell differentiationInternational Journal of Cancer, 1972
- Presence of carcinoembryonic antigen in children's colonic mucosaInternational Journal of Cancer, 1972
- Studies on Carcinoembryonic AntigenInternational Archives of Allergy and Immunology, 1972
- Demonstration of an Antigen Common to Several Varieties of NeoplasiaNew England Journal of Medicine, 1971
- The Cross-linking of Proteins with Glutaraldehyde and its use for the preparation of immunoadsorbentsImmunochemistry, 1969
- SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEMThe Journal of Experimental Medicine, 1965
- DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUESThe Journal of Experimental Medicine, 1965