Cloning, experession and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family
- 1 January 1989
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 53 (1), 23-31
- https://doi.org/10.1111/j.1469-1809.1989.tb01119.x
Abstract
We have isolated and sequenced a cDNA clone (pB8) that codes for a novel member of the cytochrome P450IIC sub-family of man. Analysis, by Southern blot hybridization, of DNA isolated from a panel of nine independent human-rodent somatic cell hybrids demonstrated that the corresponding gene (CYP2C) is located on human chromosome 10. Northern blot hybridization of RNA isolated from human livers revealed a 10-fold inter-individual variation in the expression of the gene.Keywords
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