STIMULATION BY SEROTONIN OF VASOACTIVE INTESTINAL POLYPEPTIDE RELEASE INTO RAT HYPOPHYSIAL PORTAL BLOOD
- 1 July 1982
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 111 (1), 338-340
- https://doi.org/10.1210/endo-111-1-338
Abstract
The effect of serotonin (5-HT) on plasma vasoactive intestinal polypeptide (VIP) levels in hypophysial portal blood was studied in urethane-anesthetized rats. Portal blood was collected by the parapharyngeal approach and plasma VIP was determined by radioimmunoassay. Mean (±SE) basal plasma VIP level was 1799±232 pg/ml, which was slightly decreased during the control experiments in which physiological saline was injected either intraventricularly or intravenously. Intraventricular injection of 5-HT (2 and 10 μg/rat) resulted in a significant increase in plasma VIP concentrations within 20 min. Intravenous injection of L-5-hydroxytryptophan (5-HTP, 1 mg/100 g BW), a precursor of 5-HT, also caused an increase in VIP concentrations in hypophysial portal plasma. The flow rate of hypophysial portal blood did not change throughout the experiments. These findings suggest that 5-HT stimulates VIP release from the median eminence into the hypophysial portal vessels in the rat.Keywords
This publication has 15 references indexed in Scilit:
- Vasoactive intestinal polypeptide, 5‐hydroxytryptamine and reflex hyperaemia in the small intestine of the catThe Journal of Physiology, 1980
- Effect of vasoactive intestinal polypertide on prolactin release in vitroLife Sciences, 1979
- Vasoactive Intestinal Peptide: Evidence for a Hypothalamic Site of Action to Release Growth Hormone, Luteinizing Hormone, and Prolactin in Conscious Ovariectomized Rats*Endocrinology, 1979
- Vasoactive intestinal polypeptide: Release into hypophyseal portal bloodLife Sciences, 1979
- Prolactin Release by Vasoactive Intestinal Polypeptide in Rats*Endocrinology, 1978
- The Interaction of the Serotonergic and Dopaminergic Systems on Prolactin Secretion in the Rat: The Mechanism of Action of the “Specific” Serotonin Receptor Antagonist, Methysergide*Endocrinology, 1978
- Evidence that serotonin neurons stimulate secretion of prolactin releasing factorLife Sciences, 1978
- Vasoactive Intestinal Polypeptide: Abundant Immunoreactivity in Neural Cell Lines and Normal Nervous TissueScience, 1976
- Effect of hypothalamic surgery on prolactin release induced by 5-hydroxytryptophan (5-HTP) in rats.Endocrinologia Japonica, 1976
- Collection of Hypophysial Stalk Blood in RatsEndocrinology, 1967