Acid-Reflux Disorders
- 8 September 1994
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 331 (10), 656-660
- https://doi.org/10.1056/nejm199409083311007
Abstract
In recent years, the concept of acid-reflux disorders has been broadened to include not only the effects of gastroesophageal reflux on the esophageal mucosa but also the role of acid reflux in laryngeal and pulmonary symptoms. This review discusses the effects of reflux on the esophagus, larynx, and lungs, emphasizing similarities and differences between gastrointestinal and respiratory manifestations of acid reflux.Esophageal RefluxPathophysiologyFor the past 20 years, it was assumed that the lower esophageal sphincter is the primary determinant of esophageal reflux. It is now recognized, however, that transient relaxation of the lower esophageal sphincter, not the resting . . .Keywords
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