Localization of human breast-carcinoma xenografts using antibodies to carcinoembryonic antigen
Open Access
- 1 May 1981
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 43 (5), 575-581
- https://doi.org/10.1038/bjc.1981.86
Abstract
Affinity-purified antibodies to carcinoembryonic antigen (CEA) have been injected into immune-suppressed mice bearing xenografts of human breast tumours. It has been shown that the antibodies localized in the tumours but not in normal tissues. The degree of tumour localization correlates with the amount of tumour CEA, and is unaffected by levels of circulating CEA or CEA/anti-CEA immune complexes.Keywords
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