Trimethoprim-Sulfamethoxazole
- 21 August 1980
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 303 (8), 426-432
- https://doi.org/10.1056/nejm198008213030804
Abstract
Trimethoprim–sulfamethoxazole (TMP-SMX) is a fixed combination of two antimicrobial agents — a diaminopyrimidine (trimethoprim) and a sulfonamide (sulfamethoxazole) — purposely chosen to provide sequential and synergistic inhibition of bacterial folate metabolism. Although a parenteral formulation of this combination is currently under evaluation, TMP-SMX is generally available only for oral use. It is marketed in a fixed drug ratio of one part TMP to five parts SMX (single-strength tablets contain 80 mg of TMP and 400 mg of SMX, double-strength tablets contain 160 mg of TMP and 800 mg of SMX, and an oral suspension contains 40 mg of TMP and . . .Keywords
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