Normal ranges of T4 screening values in low birthweight infants.
Open Access
- 1 March 1983
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 58 (3), 190-194
- https://doi.org/10.1136/adc.58.3.190
Abstract
Thyroxine (T4) screening values in infants of low birthweight in relation to birthweight and gestational age are reported. There were 86 healthy infants of low birthweight (group 1), and 29 preterm infants with respiratory distress syndrome (group 2). All the group 2 infants and 36% of those in group 1 had a T4 screening value below the cut-off point (-2.1 SD). In group 1 there was a significant increase in T4 with birthweight at a given gestational age, as well as with gestational age at a given birthweight. In group 2 there was also a significant increase in T4 values in relation to birthweight and gestational age, but it could not be ascertained whether this increase existed at a given gestational age or birthweight. A statistical model giving normal ranges of T4 for both groups of infants is presented, which, if applied to low birthweight infants, makes it possible to estimate the effect of low birthweight on T4 screening values, provided the birthweight and gestational age are known. In this manner the sensitivity of screening for congenital hypothyroidism is enhanced and the recall rate reduced.This publication has 20 references indexed in Scilit:
- Thyroid function studies in cord blood from premature infants with and without RDSThe Journal of Pediatrics, 1981
- Frequency of transient hypothyroxinaemia in low birthweight infants. Potential pitfall for neonatal screening programmes.Archives of Disease in Childhood, 1981
- Reduction of mortality rate in premature infants by substitution of thyroid hormonesEuropean Journal of Pediatrics, 1981
- Misleadingly Low Free Thyroxine Index and Usefulness of Reverse Triiodothyronine Measurement in Nonthyroidal IllnessesAnnals of Internal Medicine, 1979
- Thyroid function in preterm infants with respiratory distress syndromeThe Journal of Pediatrics, 1979
- Screening for congenital hypothyroidism. Results in the newborn population of New EnglandJAMA, 1978
- Transient hypothyroidism in the newborn infantThe Journal of Pediatrics, 1978
- Correlation between gestational age, weight, or ponderosity and serum thyroxine concentration at birthThe Journal of Pediatrics, 1977
- Clinical assessment of gestational age in the newborn infantThe Journal of Pediatrics, 1970
- Radioimmunoassay of Thyrotropin in Human SerumJournal of Clinical Endocrinology & Metabolism, 1965