Effects of short chain alcohols and hydrocarbon compounds on the adenylate cyclase of the skin

Abstract
The c[cyclic]AMP content of [pig] epidermal slices is increased by incubation with ethanol, the effect of which is dose-dependent from 1-5% concentration in the incubation media. n-Propanol and acetone are also effective at a concentration equimolar to 5% ethanol. This effect of ethanol is due to activation of adenylate cyclase, rather than to the inactivation of cAMP-phosphodiesterase.