STUDIES ON VI ANTIGEN
- 1 July 1954
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 60 (1), 52-62
- https://doi.org/10.1093/oxfordjournals.aje.a119703
Abstract
A study was made of the immunological response of human beings to purified Vi antigen derived from Escherichia coli 5396/38. Of a total of 432 subjects given a single subcut. injn. of 0.04 mg. of antigen, 95% developed Vi antibody. Larger amts. or multiple injns. of antigen failed to increase antibody levels. Antibody developed in response to a single small injn. persisted for periods up to 2 yrs.. This was contrasted with the rapid disappearance of Vi antibody following recovery from typhoid fever. Similarities in the response of man to the pneumococcal polysaccharides and the Vi antigen are pointed out and discussed.Keywords
This publication has 6 references indexed in Scilit:
- Evidence for an aminohexuronic acid as hydrolytic product of Vi antigenArchives of Biochemistry and Biophysics, 1954
- STUDIES ON CORTISONE AND ANTIBIOTICS FOR PROMPT THERAPEUTIC CONTROL OF TYPHOID FEVER AND SCRUB TYPHUSJCI Insight, 1954
- ENHANCEMENT OF THE IMMUNOGENICITY OF TYPHOID VACCINE BY RETENTION OF THE VI ANTIGEN12American Journal of Epidemiology, 1953
- Estimation of Vi Antibody Employing Erythrocytes Treated with Purified Vi Antigen.Experimental Biology and Medicine, 1953
- A NEW METHOD FOR STAINING BACTERIAL CAPSULESActa Pathologica Microbiologica Scandinavica, 1951
- Determination of Small Quantities of Nitrogen in Serological Precipitates and Other Biological Materials.Experimental Biology and Medicine, 1950