Attenuation of Ischemia/Reperfusion Injury in Rats by a Caspase Inhibitor
- 27 January 1998
- journal article
- other
- Published by Wolters Kluwer Health in Circulation
- Vol. 97 (3), 276-281
- https://doi.org/10.1161/01.cir.97.3.276
Abstract
Background—Z-Val-Ala-Asp(OMe)-CH2F (ZVAD-fmk), a tripeptide inhibitor of the caspase interleukin-1β–converting enzyme family of cysteine proteases, may reduce myocardial reperfusion injury in vivo ...Keywords
This publication has 7 references indexed in Scilit:
- Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.Journal of Clinical Investigation, 1996
- Intracellular IL-1beta is an inhibitor of Fas-mediated apoptosis.The Journal of Immunology, 1996
- Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis.Journal of Clinical Investigation, 1996
- Induction of Interleukin-6 Synthesis in the MyocardiumCirculation, 1995
- Recurrent ischemia in the canine heart causes recurrent bursts of free radical production that have a cumulative effect on contractile function. A pathophysiological basis for chronic myocardial "stunning".Journal of Clinical Investigation, 1995
- Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.The Journal of cell biology, 1992
- Oxygen radicals generated at reflow induce peroxidation of membrane lipids in reperfused hearts.Journal of Clinical Investigation, 1991