A microsatellite genetic linkage map for zebrafish (Danio rerio)
- 1 April 1998
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 18 (4), 338-343
- https://doi.org/10.1038/ng0498-338
Abstract
We have constructed a zebrafish genetic linkage map consisting of 705 simple sequence-length polymorphism markers (SSLPs). The map covers 2350 centimorgans (cM) of the zebrafish genome with an average resolution of 3.3 cM. It is a complete map in genetic mapping terms (there is one linkage group for each of the 25 chromosomes), and it has been confirmed by somatic-cell hybrids and centromere-mapping using half-tetrad analysis. The markers are highly polymorphic in the zebrafish strains used for genetic crosses and provide a means to compare genetic segregation of developmental mutations between laboratories. These markers will provide an initial infrastructure for the positional cloning of the nearly 600 zebrafish genes identified as crucial to vertebrate development,and will become the anchor for the physical map of the zebrafish genome.Keywords
This publication has 32 references indexed in Scilit:
- A comprehensive map of the porcine genome.Genome Research, 1996
- The zebrafish: heritable disorders in transparent embryos.JCI Insight, 1996
- A comprehensive genetic map of the mouse genomeNature, 1996
- A comprehensive genetic map of the human genome based on 5,264 microsatellitesNature, 1996
- An STS-Based Map of the Human GenomeScience, 1995
- A genetic linkage map of the laboratory rat, Rattus norvegicusNature Genetics, 1995
- A genetic map of the mouse with 4,006 simple sequence length polymorphismsNature Genetics, 1994
- A Genetic Linkage Map for the ZebrafishScience, 1994
- Towards high resolution maps of the mouse and human genomes—a facility for ordering markers to 0.1 cM resolutionHuman Molecular Genetics, 1994
- Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrateCurrent Biology, 1994