Quinacrine in the management of malignant pleural effusion

Abstract
Twenty-five patients with malignant pleural effusion were treated with a single intrapleural dose of Quinacrine. Eighteen patients (72 per cent) had a significant response, with no reaccumulation of fluid for at least 2 months following treatment up to a maximum of 18 months in 2 patients. Seven patients (28 per cent) survived for longer than 1 year without evidence of recurrent effusion.