The Asymmetric Synthesis of 4,4-Dimethyl-3-Substitutedbutyrolactones
- 1 March 1986
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 16 (3), 225-232
- https://doi.org/10.1080/00397918608076304
Abstract
Chiral 4,4-dimethyl-3-phenyl and 3-(3-oxobutyl)butyrolactones have been prepared in high enantiomeric excesses by a mild acid catalysed cleavage and lactonisation of the Michael adducts obtained from asymmetric additions of isopropenyl magnesium bromide to α,β-unsaturated carboxylic amides derived from 1-ephedrine.Keywords
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