Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression
- 1 January 1995
- journal article
- Published by Springer Nature in Molecular and Cellular Biochemistry
- Vol. 151 (1), 77-81
- https://doi.org/10.1007/bf01076899
Abstract
A complimentary DNA clone encoding the entire human palmitoyl-CoA ligase has been isolated from a liver cDNA library and sequenced in it's entirety. The predicted product is a 699 amino acid protein. Southern analysis utilizing the human palmitoyl-CoA ligase gene as a probe revealed varying degrees of similarity amongst various mammalian species. The palmitoyl-CoA ligase gene is highly expressed in liver, heart, skeletal muscle and kidney, and to a lesser extent in brain, lung, placenta and pancreas. The expression of palmitoyl-CoA ligase in various tissue parallels the function of this enzyme in the metabolism of fatty acids in these tissues.This publication has 20 references indexed in Scilit:
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